Police said that a marked vehicle was involved in the crash with a car on the A82 in Dumbarton – one of the busiest links between the central belt and the Highlands – at around 7.10am on Friday morning.
The two officers were taken to hospital, and have since been discharged after treatment.
Traffic Scotland confirmed the road was closed for around 15 minutes whilst recovery was arranged for the vehicles.
A Police Scotland spokesperson said: “A marked police vehicle was involved with a car on Stirling Road in Dumbarton around 7.10am on Friday, May 26.
“The two officers in the police vehicle were taken to hospital and have been discharged after treatment.
“Recovery was arranged for the vehicles.”