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LSU vs. Auburn odds, line, spread: 2021 college football picks, Week 5 predictions from model on 81-61 run

No. 22 Auburn Tigers go on the road to play the LSU Tigers on Saturday night. Auburn (3-1) opened the season by blowing out Akron and Alabama State before losing to Penn State and then coming from behind in a win over Georgia State last week. LSU (3-1) is coming off a three-point victory on the road against Mississippi State. The LSU Tigers have their eyes set on a fourth straight win. T.J. Finley, a former LSU quarterback, could start for Auburn after he replaced Bo Nix last week and guided Auburn to a come-from-behind win.

Kickoff from Tiger Stadium is set for 9 p.m. ET. Caesars Sportsbook lists LSU at -3 in the Auburn vs. LSU odds, while the over-under for total points is up to 56 after opening at 53.5. Before locking in any LSU vs. Auburn picks, be sure to see the college football predictions and betting advice from SportsLine’s proven model.

The model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, it enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on LSU vs. Auburn and it just revealed its CFB picks and predictions. You can visit SportsLine now to see the model’s CFB Week 5 picks. Now, here are the college football odds and betting lines for Auburn vs. LSU:

  • Auburn vs. LSU spread: LSU -3
  • Auburn vs. LSU over-under: 56 points
  • Auburn vs. LSU money line: Auburn +140, LSU -160
  • AUB: Over is 4-1 in Tigers last five games overall
  • LSU: Tigers are 5-1 ATS in their last six conference games

Featured Game | LSU Tigers vs. Auburn Tigers

Why Auburn can cover

The Tigers offense has found plenty of success during the first month of the season. Auburn is the No. 18 offense in the nation, averaging 484 total yards with 7.0 yards per play. The Tigers had two monster performances to kick off their 2021 campaign, scoring at least 60 points in back-to-back games against Akron and Alabama State.

Despite the questions at quarterback, Auburn has one of the top rushing attacks in the nation. The Tigers average 257 yards on the ground, which ranks eighth in the country. Auburn has a two-headed monster in the backfield with sophomore Tank Bigsby and freshman Jarquez Hunter. This duo combines for 196.2 yards per game on the ground. The Tigers will look to get the ball in these running backs’ hands as much as possible on Saturday night. 

Why LSU can cover

Sophomore Kayshon Boutte has been quarterback Max Johnson’s favorite target early on in the year. Boutte leads the Tigers with 24 catches for 309 yards. He has also reeled in eight touchdowns, which is tied for first in the nation. Boutte is coming off a solid game against Mississippi State where he caught four passes for 85 yards with two touchdowns.

Last year against Auburn, Boutte caught two passes for 48 yards and a score. The sophomore receiver has built a great rapport with Johnson throughout the year. Boutte averages a team-high 77.3 yards per game. This duo has connected for at least one touchdown in each game this season and will look to continue that streak on Saturday night. 

How to make Auburn vs. LSU picks

SportsLine’s model is leaning over on the total, projecting 65 combined points. It also has generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can get the pick over at SportsLine.

So who wins LSU vs. Auburn? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the Auburn vs. LSU spread to back, all from the advanced model that is up almost $3,300 on its top-rated college football spread picks, and find out.



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